Lysosome-associated membrane protein 1 is a major SSEA-1-carrier protein in mouse neural stem cells

Lysosome-associated membrane protein 1 is a major SSEA-1-carrier protein in mouse neural stem cells.

Stage-specific embryonic antigen-1 (SSEA-1) is a well-known carbohydrate antigenic epitope of undifferentiated cells, including neural stem cells (NSCs). However, the exact nature of the carrier proteins has not been fully characterized. Using proteomics analyses, we herein report that a lysosomal protein, LAMP-1, is a major carrier protein of SSEA-1 in NSCs, despite the common belief that SSEA...

GLYCO - 2010 - 00036 . R 1 Lysosome - associated membrane protein 1 is a major SSEA - 1 - carrier protein in mouse neural stem cells

Institute of Molecular Medicine and Genetics and Institute of Neuroscience, Medical College of Georgia, 1120 15 Street, Augusta, Georgia 30912, USA; Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 4678603, Japan; Institute for Molecular Science and Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, 5-1 Hi...

Lysosome - Associated Membrane Protein - 1 M 150 , Is a Posttranslational Isoform of The Th 1 - Specific

LeX/ssea-1 Is Expressed by Adult Mouse CNS Stem Cells, Identifying Them as Nonependymal

Adult neural stem cells are rare, and little is known about their unique characteristics, leaving their in vivo identity enigmatic. We show that Lewis X (LeX), a carbohydrate expressed by embryonic pluripotent stem cells, is made by adult mouse subventricular zone (SVZ) stem cells and shed into their environment. Only 4% of acutely isolated SVZ cells are LeX(+); this subpopulation, purified by ...

Lysosome-Associated Membrane Protein-2: A Major Player in the Pathogenesis of Chronic Pancreatitis

he mechanisms involved in the development of Teither acute or chronic pancreatitis are not well understood, but previous reports have suggested that the pathogenesis of acute pancreatitis may involve a blockade of autophagic flux. In the current issue of Cellular and Molecular Gastroenterology and Hepatology, Mareninova et al from the Gukovskaya and Lerch groups have reported the results of stu...